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GSK2814338

This product is for research use only, not for human use. We do not sell to patients.

GSK2814338
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$750To Be Confirmed
250mg$1350To Be Confirmed
500mg$2025To Be Confirmed
email: [email protected]        [email protected]

Cat #: V21862 CAS #: 1420367-28-7 Purity ≥ 99%

Description: GSK2814338 (GSK-2814338) is a novel and potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) with the potential to be used for atherosclerosis and Alzheimer's disease.

References: Zehong Wan, et al. Bicyclic pyrimidone compounds. WO2013014185A1.

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Molecular Weight (MW)468.38
Molecular FormulaC21H17F5N4O3
CAS No.1420367-28-7
SMILES CodeO=C1N=C(OCC2=CC(F)=C(OC3=CC=C(C(F)(F)F)N=C3)C(F)=C2)C=C4N(C)CCCN41
SynonymsGSK2814338; GSK 2814338; GSK-2814338
ProtocolIn VitroLipoprotein-associated phospholipase A2 (Lp-PLA2) is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2 travels with low-density lipoprotein (LDL) and rapidly cleaves oxidized phosphatidylcholine molecules derived from the oxidation of LDL.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1350 mL10.6751 mL21.3502 mL42.7004 mL
5mM0.4270 mL2.1350 mL4.2700 mL8.5401 mL
10mM0.2135 mL1.0675 mL2.1350 mL4.2700 mL
20mM0.1068 mL0.5338 mL1.0675 mL2.1350 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.