W-7 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $250 | Check With Us |
| 500mg | $450 | Check With Us |
| 1g | $675 | Check With Us |
: Cat #: V12983 CAS #: 61714-27-0 Purity ≥ 98%
Description: W-7 HCl is a novel, potent and selective calmodulin antagonist with antitumor activity.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 377.33 |
|---|---|
| Molecular Formula | C16H22Cl2N2O2S |
| CAS No. | 61714-27-0 |
| SMILES Code | O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCCCCCN)=O.[H]Cl |
| Synonyms | W-7 hydrochloride; W-7 HCl; W 7 HCl; W7 HCl; W-7 hydrochloride; W-7 hydrochloride; |
| Protocol | In Vitro | W-7 is distributed mainly in the cytoplasm, and inhibits proliferation of Chinese hamster ovary K1 (CHO-K1) cells. W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle. |
|---|---|---|
| In Vivo | W-7 (3 mg/kg; intraperitoneal injection; on 5 consecutive days per week; female BALB/c nu mice) treatment significantly reduces tumor growth in a murine MM model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6502 mL | 13.2510 mL | 26.5020 mL | 53.0040 mL |
| 5mM | 0.5300 mL | 2.6502 mL | 5.3004 mL | 10.6008 mL |
| 10mM | 0.2650 mL | 1.3251 mL | 2.6502 mL | 5.3004 mL |
| 20mM | 0.1325 mL | 0.6626 mL | 1.3251 mL | 2.6502 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.