THPP-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V16347 CAS #: 1257051-63-0 Purity ≥ 98%
Description: THPP-1 is a novel, potent and orally bioavailable PDE10A (phosphodiesterase 10A) inhibitor with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively.
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| Molecular Weight (MW) | 464.90 |
|---|---|
| Molecular Formula | C23H21ClN6O3 |
| CAS No. | 1257051-63-0 |
| SMILES Code | O=C(N1CCC2=NC(C3=CC=C(Cl)N=C3)=NC(OCCOC)=C2C1)C4=C5C=CC=CN5C=N4 |
| Synonyms | THPP-1 |
| Protocol | In Vitro | THPP-1 (0.1-1.0 mg/kg, p.o.) shows novel object recognition in rats[1]. THPP-1 (p.o., 1-30 mg/kg) dose-dependently increases phosphorylation of GluR1 S845 in the rat striatum whereas the total levels of GluR1 in the striatum are not affected. Administration of THPP-1 also results in an associated increase in the pGluR1/GluR1 ratios at all doses examined in this study. THPP-1 (0.1-1.0 mg/kg, p.o.) shows novel object recognition in rats. |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1510 mL | 10.7550 mL | 21.5100 mL | 43.0200 mL |
| 5mM | 0.4302 mL | 2.1510 mL | 4.3020 mL | 8.6040 mL |
| 10mM | 0.2151 mL | 1.0755 mL | 2.1510 mL | 4.3020 mL |
| 20mM | 0.1076 mL | 0.5378 mL | 1.0755 mL | 2.1510 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
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%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.