Lodenafil

This product is for research use only, not for human use. We do not sell to patients.

Lodenafil
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$1150To Be Confirmed
1g$1950To Be Confirmed
5g$2925To Be Confirmed

Cat #: V18975 CAS #: 139755-85-4 Purity ≥ 99%

Description: Lodenafil (also known as hydroxyhomosildenafil; trade name Helleva), an analog of sildenafil, is a novel and potent phosphodiesterase PDE5 inhibitor with the potential to treat erectile dysfunction (ED).

References: Toque HA, et al. Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum. Eur J Pharmacol. 2008 Sep 4;591(1-3):189-95.

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Molecular Weight (MW)504.60
Molecular FormulaC23H32N6O5S
CAS No.139755-85-4
SMILES CodeO=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1
SynonymsLodenafil; hydroxyhomosildenafil; trade name Helleva
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9818 mL9.9088 mL19.8177 mL39.6354 mL
5mM0.3964 mL1.9818 mL3.9635 mL7.9271 mL
10mM0.1982 mL0.9909 mL1.9818 mL3.9635 mL
20mM0.0991 mL0.4954 mL0.9909 mL1.9818 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.