Ro20-1724

This product is for research use only, not for human use. We do not sell to patients.

Ro20-1724
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$250Check With Us
1g$450Check With Us
5g$1140Check With Us

Cat #: V13925 CAS #: 29925-17-5 Purity ≥ 99%

Description: Ro20-1724 (Ro-201724) is a novel and potent inhibitor of cyclic nucleotide phosphodiesterase with neuroprotective effects. It shows selectivity for PDE4.

References: Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854. 

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Molecular Weight (MW)278.35
Molecular FormulaC15H22N2O3
CAS No.29925-17-5
SMILES CodeO=C1NC(CC2=CC=C(OC)C(OCCCC)=C2)CN1
SynonymsRo20-1724; Ro 20-1724; Ro-20-1724
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.5926 mL17.9630 mL35.9260 mL71.8520 mL
5mM0.7185 mL3.5926 mL7.1852 mL14.3704 mL
10mM0.3593 mL1.7963 mL3.5926 mL7.1852 mL
20mM0.1796 mL0.8981 mL1.7963 mL3.5926 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.