Vesnarinone (OPC8212)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$850	Check With Us
500mg	$1550	Check With Us
1g	$2325	Check With Us

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Cat #: V27984 CAS #: 81840-15-5 Purity ≥ 99%

Description: Vesnarinone (OPC-8212) is a quinolinone-based cardiotonic agent, acting as a mixed phosphodiesterase 3 (PDE3) inhibitor and ion-channel modifier with modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity.

References: A Matsumori, et al. Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure. Circulation. 1994 Mar;89(3):955-8.

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Molecular Weight (MW)	395.45
Molecular Formula	C22H25N3O4
CAS No.	81840-15-5
SMILES Code	O=C1NC2=C(C=C(N3CCN(C(C4=CC=C(OC)C(OC)=C4)=O)CC3)C=C2)CC1
Synonyms	Vesnarinone; Arkin; Arkin-Z; RG-0210; RG 0210; RG0210; OPC-8212; OPC 8212; OPC8212; Piteranometozine;

Protocol	In Vitro	Vesnarinone (60 and 100 μg/mL; 48 h) inhibits the cell growth in a dose-dependent manner.
Protocol	In Vivo	Vesnarinone (oral gavage; 300 mg/kg; once daily; 6 w) binds covalently to rat liver in vivo.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5288 mL	12.6438 mL	25.2876 mL	50.5753 mL
5mM	0.5058 mL	2.5288 mL	5.0575 mL	10.1151 mL
10mM	0.2529 mL	1.2644 mL	2.5288 mL	5.0575 mL
20mM	0.1264 mL	0.6322 mL	1.2644 mL	2.5288 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.