SPDB-DM4 | CAS 1626359-62-3

SPDB-DM4

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$4050	To Be Confirmed
200mg	$6050	To Be Confirmed
500mg	$10200	To Be Confirmed

: [email protected] [email protected]

Cat #: V32471 CAS #: 1626359-62-3 Purity ≥ 99%

Description: SPDB-DM4 is a novel drug-linker conjugate used for the synthesis of antibody-drug-conjugate (ADC) with maytansine as the payload (DM4) which is connected to the antibody part via a SPDB linker, exhibiting potent anti-tumor activity.

References: [1]. Puja Sapra, et al. Investigational antibody drug conjugates for solid tumors. Expert Opin Investig Drugs. 2011 Aug;20(8):1131-49.

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Molecular Weight (MW)	995.59
Molecular Formula	C46H63ClN4O14S2
CAS No.	1626359-62-3
Solubility In Vitro	DMSO : ≥ 300 mg/mL (301.33 mM)
SMILES Code	C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
Synonyms	SPDB-DM4;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.0044 mL	5.0221 mL	10.0443 mL	20.0886 mL
5mM	0.2009 mL	1.0044 mL	2.0089 mL	4.0177 mL
10mM	0.1004 mL	0.5022 mL	1.0044 mL	2.0089 mL
20mM	0.0502 mL	0.2511 mL	0.5022 mL	1.0044 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.