CL2A-SN-38 | CAS 1279680-68-0 (free base)

CL2A-SN-38

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$550	In Stock
200mg	$825	In Stock
500mg	$1375	In Stock

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Cat #: V33342 CAS #: 1279680-68-0 (free base) Purity ≥ 98%

Description: CL2A-SN-38, an SN-38 (topoisomerase-I inhibitor) analogue, is a peptide-based drug linker used to synthesize antibody drug conjugates (ADC). It is composed of a potent DNA Topoisomerase I inhibitor SN-38 and a linker CL2A, which provides significant and specific anticancer effects against a panel of human solid tumors. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types.

References: Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1738.506
Molecular Formula	C77H101Cl4N11O26
CAS No.	1279680-68-0 (free base)
SMILES Code	O=C(O[C@@]1(CC)C2=C(C(N3CC4=C(C5=CC(O)=CC=C5N=C4C3=C2)CC)=O)COC1=O)OCC6=CC=C(C=C6)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CC8)CN9C(C=CC9=O)=O)=O)=C7)=O)=O)CCCCN)=O.O=C(O)C(Cl)Cl.O=C(O)C(Cl)Cl
Synonyms	CL2A-SN38 DCA salt; CL2A-SN38 dichloroacetic acid; CL2A-SN-38; CL2ASN-38; CL2A SN 38; CL2A-SN 38; CL2A-SN38; CL2ASN38;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.5752 mL	2.8760 mL	5.7521 mL	11.5041 mL
5mM	0.1150 mL	0.5752 mL	1.1504 mL	2.3008 mL
10mM	0.0575 mL	0.2876 mL	0.5752 mL	1.1504 mL
20mM	0.0288 mL	0.1438 mL	0.2876 mL	0.5752 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.