Val-Cit-PAB-MMAE

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$4090	Check With Us
200mg	$6125	Check With Us
500mg	$10325	Check With Us

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Cat #: V29789 CAS #: 644981-35-1 Purity ≥ 99%

Description: Val-Cit-PAB-MMAE is a drug-linker conjugate used for preparing ADC (antibody-drug-conjugate) with monomethyl auristatin E (MMAE), a highly potent anti-mitotic agent as a cytotoxicin/warhead, linked via the peptide Val-Cit-PAB.

References: [1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

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Molecular Weight (MW)	1123.43
Molecular Formula	C58H94N10O12
CAS No.	644981-35-1
Solubility In Vitro	DMSO : ≥ 110 mg/mL (97.91 mM)
Synonyms	CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O)=O)C=C3)=O)C)=O)=O)C

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.8901 mL	4.4507 mL	8.9013 mL	17.8026 mL
5mM	0.1780 mL	0.8901 mL	1.7803 mL	3.5605 mL
10mM	0.0890 mL	0.4451 mL	0.8901 mL	1.7803 mL
20mM	0.0445 mL	0.2225 mL	0.4451 mL	0.8901 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.