TST-A | CAS 1426953-21-0

TST-A

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200mg	$8250	Check With Us
500mg	$13900	Check With Us

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Cat #: V2228 CAS #: 1426953-21-0 Purity ≥ 99%

Description: TST-A , also known as Thailanstatin A, is a potent antiproliferative agent, which was isolated from the fermentation broth of B. thailandensis MSMB43

References: [1]. Puthenveetil S, et al. Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads. Bioconjug Chem. 2016;27(8):1880-1888.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	535.63
Molecular Formula	C28H41NO9
CAS No.	1426953-21-0
SMILES Code	O=C(O)C[C@H](C1)O[C@H](/C=C/C(C)=C/C[C@@H]2O[C@H](C)[C@H](NC(/C=C[C@@H](OC(C)=O)C)=O)C[C@@H]2C)[C@@H](O)[C@@]31CO3
Synonyms	Thailanstatin A; TST-A;

Protocol	In Vitro	Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43. Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI50s in the single nM range (1.11-2.69 nM).

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8670 mL	9.3348 mL	18.6696 mL	37.3392 mL
5mM	0.3734 mL	1.8670 mL	3.7339 mL	7.4678 mL
10mM	0.1867 mL	0.9335 mL	1.8670 mL	3.7339 mL
20mM	0.0933 mL	0.4667 mL	0.9335 mL	1.8670 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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