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N-Me-L-Ala-maytansinol

This product is for research use only, not for human use. We do not sell to patients.

N-Me-L-Ala-maytansinol
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1450Check With Us
500mg$2250Check With Us
1g$3375Check With Us
email: [email protected]        [email protected]

Cat #: V37613 CAS #: 77668-69-0 Purity ≥ 99%

Description: N-Me-L-Ala-maytansinol is a maytansine derivative used as the warhead for antibody-drug conjugate (ADC).

References: [1]. Nittoli T, et al. Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279.

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Molecular Weight (MW)650.16
Molecular FormulaC32H44ClN3O9
CAS No.77668-69-0
SMILES CodeC[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)NC)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
SynonymsMaytansinol-Ala; N-Me-L-Ala-maytansinol;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5381 mL7.6904 mL15.3808 mL30.7617 mL
5mM0.3076 mL1.5381 mL3.0762 mL6.1523 mL
10mM0.1538 mL0.7690 mL1.5381 mL3.0762 mL
20mM0.0769 mL0.3845 mL0.7690 mL1.5381 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.