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BMS-186511

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BMS-186511
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Cat #: V5478 CAS #: 167467-53-0 Purity ≥ 98%

Description: BMS-186511 is a novel and potent Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a closely related enzyme. Thus, it is conceivable that FT inhibitors may ultimately become the first generation of drugs against the malignant phenotype in NF1 based on rational insights into the mechanism of action of neurofibromin.

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Molecular FormulaC34H60N3O7PS
CAS No.167467-53-0
SMILES CodeCSCC[C@@H](C(OC)=O)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CCP(C/C=C(C)/CC/C=C(C)/CC/C=C(C)C)
Quality Control Documentation
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Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
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