Deacylcortivazol (DAC)

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V5523 CAS #: 4906-84-7 Purity ≥ 98%

Description: Deacylcortivazol (DAC) is a novel and potent glucocorticoid agent that contains a phenyl-pyrazole group fused to the 2-3 position of the conventional steroid core. When incubated with glucocorticoid-resistant mutants derived from the glucocorticoid-sensitive human leukemic cell line CEM-C7, DAC caused significant growth inhibition. The cytotoxicity of DAC at concentrations higher than necessary for glucocorticoid receptor saturation is not mediated by glucocorticoid receptors. Thus, DAC may be a bifunctional compound having both steroid receptor-mediated and receptor-independent cytotoxicity.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	488.63
Molecular Formula	C30H36N2O4
CAS No.	4906-84-7
Synonyms	Deacylcortivazol; DAC; NSC 325316; UNII-3JO09QT49F; NSC325316; UNII3JO09QT49F; NSC-325316; UNII 3JO09QT49F

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0465 mL	10.2327 mL	20.4654 mL	40.9308 mL
5mM	0.4093 mL	2.0465 mL	4.0931 mL	8.1862 mL
10mM	0.2047 mL	1.0233 mL	2.0465 mL	4.0931 mL
20mM	0.1023 mL	0.5116 mL	1.0233 mL	2.0465 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.