R-10015
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1200 | Check With Us |
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
: Cat #: V31728 CAS #: 2097938-51-5 Purity ≥ 99%
Description: R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
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- Related Biological Data
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| Molecular Weight (MW) | 410.86 |
|---|---|
| Molecular Formula | C20H19ClN6O2 |
| CAS No. | 2097938-51-5 |
| Protocol | In Vitro | R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells. R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release. R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) |
|---|---|---|
| In Vivo | R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections | |
| Animal model | 6-8 weeks female C3H/HeN mice | |
| Dosages | 10 mg/kg | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4339 mL | 12.1696 mL | 24.3392 mL | 48.6784 mL |
| 5mM | 0.4868 mL | 2.4339 mL | 4.8678 mL | 9.7357 mL |
| 10mM | 0.2434 mL | 1.2170 mL | 2.4339 mL | 4.8678 mL |
| 20mM | 0.1217 mL | 0.6085 mL | 1.2170 mL | 2.4339 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.