Monastrol
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1060 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V2718 CAS #: 329689-23-8 Purity ≥ 98%
Description: Monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cell lines.
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| Molecular Weight (MW) | 292.35 |
|---|---|
| Molecular Formula | C14H16N2O3S |
| CAS No. | 329689-23-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 58 mg/mL (198.39 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:58 mg/mL (198.39 mM) | |
| Synonyms | (±)-Monastrol |
| Protocol | In Vitro | Monastrol is a small molecule that permeates cells that blocks cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family. Monastrol treatment of dividing cells results in spindle collapse and monostar spindle cell cycle arrest, similar to the phenotype observed when Eg5 is inhibited by anti-EG5 antibodies |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4206 mL | 17.1028 mL | 34.2056 mL | 68.4112 mL |
| 5mM | 0.6841 mL | 3.4206 mL | 6.8411 mL | 13.6822 mL |
| 10mM | 0.3421 mL | 1.7103 mL | 3.4206 mL | 6.8411 mL |
| 20mM | 0.1710 mL | 0.8551 mL | 1.7103 mL | 3.4206 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.