Exo1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $650 | Check With Us |
| 1g | $975 | Check With Us |
: Cat #: V4001 CAS #: 75541-83-2 Purity ≥ 98%
Description: Exo-1 (Exo1) is a novel, potent and reversible inhibitor of exocytosis which is used as a chemical inhibitor of the exocytic pathway.
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- Related Biological Data
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| Molecular Weight (MW) | 273.26 |
|---|---|
| Molecular Formula | C15H12FNO3 |
| CAS No. | 75541-83-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(OC)C1=CC=CC=C1NC(C2=CC=C(F)C=C2)=O |
| Synonyms | Exo1; Exo 1; Exo-1 |
| Protocol | In Vitro | Exo1 is a modifier of Golgi ARF1 GTPase activity. Because Exo1 affects a subset of the membrane events that are blocked by BFA, but seems to have a different protein target (and presumably has different side effects), it provides an independent means to interfere with Golgi activity. Exo1 Disrupts Vesicular Traffic from the ER to the Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of ~20 μM. Exo1 prevents acquisition of endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP, transferrin, and MHC class I. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6595 mL | 18.2976 mL | 36.5952 mL | 73.1904 mL |
| 5mM | 0.7319 mL | 3.6595 mL | 7.3190 mL | 14.6381 mL |
| 10mM | 0.3660 mL | 1.8298 mL | 3.6595 mL | 7.3190 mL |
| 20mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 3.6595 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.