SW044248
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1080 | Check With Us |
| 500mg | $1880 | Check With Us |
| 1g | $2820 | Check With Us |
: Cat #: V2893 CAS #: 522650-83-5 Purity ≥ 98%
Description: SW044248 is a novel, potent and selective Topoisomerase I inhibitor that was identified through a screen for chemicals selectively toxic for non-small cell lung cancer (NSCLC) cell lines.
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| Molecular Weight (MW) | 421.52 |
|---|---|
| Molecular Formula | C22H23N5O2S |
| CAS No. | 522650-83-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 30 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC(C(NC4=CC=CC=C4OC)=O)CC |
| Synonyms | SW044248; SW-044248; SW 044248 |
| Protocol | In Vitro | SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21CDKN1A |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3724 mL | 11.8618 mL | 23.7237 mL | 47.4473 mL |
| 5mM | 0.4745 mL | 2.3724 mL | 4.7447 mL | 9.4895 mL |
| 10mM | 0.2372 mL | 1.1862 mL | 2.3724 mL | 4.7447 mL |
| 20mM | 0.1186 mL | 0.5931 mL | 1.1862 mL | 2.3724 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.