ISRIB (mixed cis- and trans-isomer)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $550 | Check With Us |
| 500mg | $1000 | Check With Us |
| 1g | $1500 | Check With Us |
: Cat #: V41046 CAS #: 548470-11-7 Purity ≥ 98%
Description: ISRIB (mixed cis- and trans-isomer) is a novel and potent ISR (Integrated Stress Response) Inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 451.344 |
|---|---|
| Molecular Formula | C22H24Cl2N2O4 |
| CAS No. | 548470-11-7 |
| Protocol | In Vitro | The administration of ISRIB significantly inhibited the apoptosis of NSCs, and the flow results were consistent with the in vivo results (Figures 5(d) and 5(e)). The above results suggest that ISRIB administration alleviates the apoptosis of NSCs induced by hypoxic exposure. |
|---|---|---|
| In Vivo | Alizarin red staining, calcium content, and ALP activity in the rat aorta were used to determine whether ISRIB could ameliorate VC progression. The increased calcium content and ALP activity in the calcified aorta were rescued by ISRIB treatment (Fig. 1B, C). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2156 mL | 11.0780 mL | 22.1560 mL | 44.3121 mL |
| 5mM | 0.4431 mL | 2.2156 mL | 4.4312 mL | 8.8624 mL |
| 10mM | 0.2216 mL | 1.1078 mL | 2.2156 mL | 4.4312 mL |
| 20mM | 0.1108 mL | 0.5539 mL | 1.1078 mL | 2.2156 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.