ML327
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2650 | Check With Us |
| 250mg | $3886 | Check With Us |
| 500mg | $5830 | Check With Us |
: Cat #: V4012 CAS #: 1883510-31-3 Purity ≥ 98%
Description: ML327 is a novel potent MYC blocker which also de-represses E-cadherin transcription, partially reverses EMT (Epithelial-to-Mesenchymal Transition), and inhibits cancer cell invasiveness and tumor cell migration in vitro and in vivo.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 366.38 |
|---|---|
| Molecular Formula | C19H18N4O4 |
| CAS No. | 1883510-31-3 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 30mg/mLrr |
| Water: N/Arr | |
| Ethanol: N/A | |
| Synonyms | ML 327; ML327; ML-327; |
| Protocol | In Vivo | ML327 treatment significantly reduced tumor volume threefold during two-week treatment (p=0.02). The tumor explant weight of ML327-treated mice was approximately three times smaller (p=0.01). Mice treated with ML327 lost 12% more body weight than vehicle-treated mice. ML327 treatment resulted in a twofold decrease in MYCN expression, confirming that ML327 inhibited xenograft MYCN expression (p=0.0035) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7294 mL | 13.6470 mL | 27.2941 mL | 54.5881 mL |
| 5mM | 0.5459 mL | 2.7294 mL | 5.4588 mL | 10.9176 mL |
| 10mM | 0.2729 mL | 1.3647 mL | 2.7294 mL | 5.4588 mL |
| 20mM | 0.1365 mL | 0.6824 mL | 1.3647 mL | 2.7294 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.