Phthalazinone pyrazole
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1450 | Check With Us |
| 250mg | $2350 | Check With Us |
| 500mg | $3525 | Check With Us |
: Cat #: V4347 CAS #: 880487-62-7 Purity ≥ 99%
Description: Phthalazinone pyrazole is a potent, selective, and orally bioavailable inhibitor of Aurora A kinase (IC50 = 31 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 317.34 |
|---|---|
| Molecular Formula | C18H15N5O |
| CAS No. | 880487-62-7 |
| Protocol | In Vitro | Phthalazinone pyrazole (1 and 10 μM; 5 and 17 days) suppresses the EMT and induced maturation of HLCs through the inhibition of the AKT signaling pathway by the off target effect with concomitant upregulation of HNF4α rather than direct inhibition of Aurora-A. The result is confirmed by western blot and qPCR |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1512 mL | 15.7560 mL | 31.5119 mL | 63.0239 mL |
| 5mM | 0.6302 mL | 3.1512 mL | 6.3024 mL | 12.6048 mL |
| 10mM | 0.3151 mL | 1.5756 mL | 3.1512 mL | 6.3024 mL |
| 20mM | 0.1576 mL | 0.7878 mL | 1.5756 mL | 3.1512 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.