Ro3280 (Ro5203280)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2550 | Check With Us |
| 1g | $3825 | Check With Us |
: Cat #: V1579 CAS #: 1062243-51-9 Purity ≥ 98%
Description: RO3280 (also known as Ro-5203280; RO 3280; Ro5203280; RO-3280) is a novel, potent and highly selective inhibitor of Polo-like kinase 1 (PLK1) with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 543.61 |
|---|---|
| Molecular Formula | C27H35F2N7O3 |
| CAS No. | 1062243-51-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (184.0 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 100 mg/mL (184.0 mM) | |
| Synonyms | Ro5203280; RO3280; Ro5203280; RO-3280; Ro-5203280; RO 3280; Ro 5203280; 4-((9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide |
| Protocol | In Vitro | Ro3280 shows strong activity in H82, H69, A549 lung cancer cell lines, EC50 6 nM, 7 nM, and 82 nM, respectively. Ro3280 also inhibits several other cancer cell lines at lower concentrations |
|---|---|---|
| In Vivo | Ro3280 (RO3280, 40 mg/kg, iv) inhibited tumor growth by 29% in mouse xenograft models implanted with HT-72 colorectal cancer cells, and RO3280 completely inhibited tumor growth when administered more frequently |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8396 mL | 9.1978 mL | 18.3955 mL | 36.7911 mL |
| 5mM | 0.3679 mL | 1.8396 mL | 3.6791 mL | 7.3582 mL |
| 10mM | 0.1840 mL | 0.9198 mL | 1.8396 mL | 3.6791 mL |
| 20mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 1.8396 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.