NMS-P937 (NMS1286937; Onvansertib)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $779 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V1580 CAS #: 1034616-18-6 Purity ≥ 98%
Description: NMS-P937 (also know as NMS-P937; NMS1286937; NMS-P-937; NMS-P 937; Onvansertib) is an orally bioavailable, potent, selective, small-molecule Polo-like Kinase 1 (PLK1) inhibitor with potential antitumor activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 532.52 |
|---|---|
| Molecular Formula | C24H27F3N8O3 |
| CAS No. | 1034616-18-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 42 mg/mL (78.9 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 10 mg/mL (18.8 mM) | |
| Synonyms | NMS-P937; NMS1286937; NMS-P-937; NMS-P 937; NMS 1286937; NMS-1286937 |
| Protocol | In Vitro | NMS-1286937 is a potent, selective, orally available PLK1 inhibitor, IC50 The value is 2 nM. NMS-1286937 also showed inhibitory activity against FLT3, MELK and CK2, IC50 The values are 510, 744, and 826 nM, respectively |
|---|---|---|
| In Vivo | NMS-1286937 (45 mg/kg, iv) demonstrated good tumor growth inhibition and acceptable and reversible weight loss in human HCT116 colon adenocarcinoma cell xenografted CD1 nu/nu mouse tumor models. NMS-1286937 (60 mg/kg, oral) also inhibits tumor growth on HCT116 tumor xenograft models |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8779 mL | 9.3893 mL | 18.7786 mL | 37.5573 mL |
| 5mM | 0.3756 mL | 1.8779 mL | 3.7557 mL | 7.5115 mL |
| 10mM | 0.1878 mL | 0.9389 mL | 1.8779 mL | 3.7557 mL |
| 20mM | 0.0939 mL | 0.4695 mL | 0.9389 mL | 1.8779 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.