LY3177833 | CAS 1627696-51-8

LY3177833

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1020	To Be Confirmed.
500mg	$1480	To Be Confirmed.
1g	$2220	To Be Confirmed.

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Cat #: V4870 CAS #: 1627696-51-8 Purity ≥ 98%

Description: LY3177833, extracted from patent US 20140275131 and patent WO 2014143601 A1 compound 4, is a novel and potent CDC7 (Cell Division Cycle 7-related Protein Kinase) and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.

References: Robert Dean Dally, et al. CDC7 Inhibitors. Patent WO2014143601A1.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	309.30
Molecular Formula	C16H12FN5O
CAS No.	1627696-51-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vivo	LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation
	Animal model	Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells
	Dosages	10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
	Administration	Oral gavage; twice a day for 2 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2331 mL	16.1655 mL	32.3311 mL	64.6621 mL
5mM	0.6466 mL	3.2331 mL	6.4662 mL	12.9324 mL
10mM	0.3233 mL	1.6166 mL	3.2331 mL	6.4662 mL
20mM	0.1617 mL	0.8083 mL	1.6166 mL	3.2331 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.