Palbociclib (PD-0332991)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $250 | In Stock |
| 1g | $420 | In Stock |
| 5g | $1200 | In Stock |
: Cat #: V3044 CAS #: 571190-30-2 Purity ≥ 98%
Description: Palbociclib (formerly PD-0332991; PD0332991; Pfizer trade name Ibrance) is a highly selective, orally bioavailable pyridopyrimidine-based CDK4/6 inhibitor that has been approved for cancer treatment.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 447.54 |
|---|---|
| Molecular Formula | C24H29N7O2 |
| CAS No. | 571190-30-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Synonyms | PD0332991, Palbociclib free base, PD-0332991; PD 0332991; Trade name: Ibrance. |
| Protocol | In Vitro | Palbociclib (0-1 μM, 24 h) inhibits Ser in MDA-MB-435 cells795 Rb phosphorylation of the site, IC50 The value was 0.063 μM and a similar effect was obtained for Colo-205 in colon cancer Ser780 and Ser795 Effects of phosphorylation. |
|---|---|---|
| In Vivo | Palbociclib (orally, 75 or 150 mg/kg once daily for 14 days) causes rapid tumor regression and delays tumor growth. | |
| Animal model | Mice bearing Colo-205 colon carcinoma xenografts (p16 deleted) | |
| Dosages | 75, 150 mg/kg, daily for 14 days | |
| Administration | Oral adminstration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2344 mL | 11.1722 mL | 22.3444 mL | 44.6887 mL |
| 5mM | 0.4469 mL | 2.2344 mL | 4.4689 mL | 8.9377 mL |
| 10mM | 0.2234 mL | 1.1172 mL | 2.2344 mL | 4.4689 mL |
| 20mM | 0.1117 mL | 0.5586 mL | 1.1172 mL | 2.2344 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.