AT7519 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $850 | Check With Us |
| 1g | $1275 | Check With Us |
: Cat #: V1539 CAS #: 902135-91-5 Purity ≥ 98%
Description: AT7519 HCl, the hydrochloride salt of AT7519 (AT-7519 ), is a potent, orally bioavailable small molecule CDK inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 418.71 |
|---|---|
| Molecular Formula | C16H18Cl3N5O2 |
| CAS No. | 902135-91-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 52 mg/mL (124.2 mM)r |
| Water: 43 mg/mL (102.7 mM)r | |
| Ethanol: 28 mg/mL (66.9 mM) | |
| Solubility In Vivo | Saline: 30 mg/mL |
| Synonyms | AT-7519 HCl; AT7519; AT 7519 |
| Protocol | In Vitro | AT7519 Hydrochloride (0-4 μM) produces dose-dependent cytotoxicity, IC in MM cells50 The range is 0.5 to 2 μM, and this induced cytotoxicity is associated with GSK-3β activation, not transcriptional inhibition. AT7519 Hydrochloride overcomes the proliferative advantages conferred by cytokines and the protective effects of BMSCs. AT7519 Hydrochloride (0.5 μM) induces apoptosis in MM cells in a time-dependent manner. In addition, AT7519 Hydrochloride (0.5 μM) inhibits phosphorylation of RNA polymerase II CTD and partially inhibits RNA synthesis in MM.1S cells |
|---|---|---|
| In Vivo | AT7519 Hydrochloride inhibits tumor growth in a human MM xenograft mouse model |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3883 mL | 11.9414 mL | 23.8829 mL | 47.7658 mL |
| 5mM | 0.4777 mL | 2.3883 mL | 4.7766 mL | 9.5532 mL |
| 10mM | 0.2388 mL | 1.1941 mL | 2.3883 mL | 4.7766 mL |
| 20mM | 0.1194 mL | 0.5971 mL | 1.1941 mL | 2.3883 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.