BI-1347
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1100 | Check With Us |
| 500mg | $1700 | Check With Us |
| 1g | $2550 | Check With Us |
: Cat #: V4715 CAS #: 2163056-91-3 Purity ≥ 98%
Description: BI-1347 is a novel, potent and selective CDK8 inhibitor with an IC50 of 1.1 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 356.42 |
|---|---|
| Molecular Formula | C22H20N4O |
| CAS No. | 2163056-91-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | BI-1347 (150 nM; 44 h) enhances granzyme B (GZMB+) production in mouse splenic NK cells. BI-1347 (0.1 nM-10 μM; 24 h) treatment increases perforin secretion from NK92MI cells. |
|---|---|---|
| In Vivo | BI-1347 (oral gavage; 10 mg/kg; once daily; 30 d) modulates STAT1S727 phosphorylation and shows anti-tumor activity in vivo. BI-1347 (oral gavage; 10 mg/kg) intermittent schedule and BI-8382 continuous treatment combination treatment increases efficacy compared to each monotherapy in the mammary carcinoma EMT6 model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8057 mL | 14.0284 mL | 28.0568 mL | 56.1136 mL |
| 5mM | 0.5611 mL | 2.8057 mL | 5.6114 mL | 11.2227 mL |
| 10mM | 0.2806 mL | 1.4028 mL | 2.8057 mL | 5.6114 mL |
| 20mM | 0.1403 mL | 0.7014 mL | 1.4028 mL | 2.8057 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.