Abemaciclib (LY2835219) mesylate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$290	In Stock
1g	$510	In Stock
5g	$1380	In Stock

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Cat #: V1547 CAS #: 1231930-82-7 Purity ≥ 98%

Description: Abemaciclib mesylate (formerly known as LY-2835219; LY2835219; trade name: Verzenio) is a potent and selective, orally bioavailable dual inhibitor of CDK4 (cyclin-dependent kinase) and CDK6 with potential antineoplastic activity.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	602.7
Molecular Formula	C27H32F2N8.CH4O3S
CAS No.	1231930-82-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 83 mg/mL (137.7 mM)r
	Water: 100 mg/mL (165.9 mM)r
	Ethanol: 24 mg/mL (39.8 mM)
Solubility In Vivo	Water: 100 mg/mL (165.9 mM)
Synonyms	Abemaciclib; LY-2835219 mesylate; LY2835219; LY 2835219; Abemaciclib mesylate; Chemical Name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine mesylate SMILES Code: CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C.OS(=O)(C)=O Exact Mass: 602.2599

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.6592 mL	8.2960 mL	16.5920 mL	33.1840 mL
5mM	0.3318 mL	1.6592 mL	3.3184 mL	6.6368 mL
10mM	0.1659 mL	0.8296 mL	1.6592 mL	3.3184 mL
20mM	0.0830 mL	0.4148 mL	0.8296 mL	1.6592 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.