Palbociclib (PD0332991) Isethionate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$600	Check With Us
2g	$900	Check With Us
5g	$1500	Check With Us

: [email protected] [email protected]

Cat #: V1557 CAS #: 827022-33-3 Purity ≥ 98%

Description: Palbociclib Isethionate (formerly known as PD0332991; PD-0332991; Ibrance), the isethionate salt of Palbociclib, is an orally bioavailable pyridopyrimidine-based inhibitor of CDK4/6 with potential antitumor activity and was approved as an anticancer drug.

References: Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	573.66
Molecular Formula	C24H29N7O2.C2H6O4S
CAS No.	827022-33-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: <1 mg/mLr
	Water: 50 mg/mL (87.2 mM)r
	Ethanol:<1 mg/mL
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	PD0332991 isethionate salt, PD-0332991; PD 0332991; Palbociclib isethionate salt, Trade name: Ibrance

Protocol	In Vitro	Palbociclib isethionate dihydrochloride (0-1 μM, 24 h) inhibits Ser in MDA-MB-435 cells795 Rb phosphorylation of the site, IC50 The value was 0.063 μM and similar results were obtained for Colo-205 in colon cancer Ser780 and Ser795 Effects of phosphorylation
	In Vivo	Palbociclib isethionate (orally, 75 or 150 mg/kg once daily for 14 days) causes rapid tumor regression and delays tumor growth
	Animal model	Mice bearing Colo-205 colon carcinoma xenografts (p16 deleted)
	Dosages	75, 150 mg/kg, daily for 14 days
	Administration	Oral adminstration

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7432 mL	8.7160 mL	17.4319 mL	34.8639 mL
5mM	0.3486 mL	1.7432 mL	3.4864 mL	6.9728 mL
10mM	0.1743 mL	0.8716 mL	1.7432 mL	3.4864 mL
20mM	0.0872 mL	0.4358 mL	0.8716 mL	1.7432 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.