NG 52
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1440 | Check With Us |
| 500mg | $2160 | Check With Us |
| 1g | $3240 | Check With Us |
: Cat #: V5257 CAS #: 212779-48-1 Purity ≥ 98%
Description: NG 52 (NG-52), a tri-substituted purine, is a cell-permeable, reversible, and ATP-competitve inhibitor of the cell cycle-regulating kinase, Cdc28p with IC50 of 7 μM, and the related Pho85p kinase with IC50 of 2 μM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 346.81 |
|---|---|
| Molecular Formula | C16H19ClN6O |
| CAS No. | 212779-48-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | NG 52 dose-dependently inhibits the proliferation of glioma U87 and the GI of U251 cell lines50 The values were 7.8 μM and 5.2 μM, respectively, while effectively inhibiting the proliferation of primary glioma cells |
|---|---|---|
| In Vivo | NG 52 (50-150 mg/kg； oral administration; Every day; for 13 days) Inhibitor dose-dependent inhibition of glioma xenograft growth |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8834 mL | 14.4171 mL | 28.8342 mL | 57.6685 mL |
| 5mM | 0.5767 mL | 2.8834 mL | 5.7668 mL | 11.5337 mL |
| 10mM | 0.2883 mL | 1.4417 mL | 2.8834 mL | 5.7668 mL |
| 20mM | 0.1442 mL | 0.7209 mL | 1.4417 mL | 2.8834 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.