Riviciclib (P276-00)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1250	Check With Us
250mg	$1950	Check With Us
500mg	$2925	Check With Us

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Cat #: V1549 CAS #: 920113-02-6 Purity ≥ 98%

Description: Riviciclib (formerly P 276-00; P-27600; P276-00) is a flavonoid analog which acts as a potent inhibitor of CDK1 (cyclin-dependent kinase), CDK4 and CDK9 with potential antitumor activity. It inhibits CDK1/4/9 with IC50s of 79 nM, 63 nM and 20 nM, respectively.

References: Joshi KS,et al. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007 Mar;6(3):926-34.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	401.84
Molecular Formula	C21H20ClNO5
CAS No.	920113-02-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 88 mg/mL (200.8 mM)r
	Water: 88 mg/mL (200.8 mM)r
	Ethanol: 7 mg/mL (16.0 mM)
Solubility In Vivo	30% Propylene glycol, 5% Tween 80, 65% D5W: 30mg/mL
Synonyms	P-27600; P-276-00; P 276-00; P 27600; P27600; P276-00; Riviciclib HCl

Protocol	In Vitro	Riviciclib (1.5-5 μM; 72 hours) shows no detectable cells in G1 and G2 in promyelocytic leukemia cells and arrest of cells in G1 in synchronized human non-small cell lung carcinoma (H-460) and human normal lung fibroblast (WI-38) cells
	In Vivo	Riviciclib (administered i.p.; 35 kg/mg daily for 10 days, in human xenograft mode with severe combined immunodeficient mice) shows significant inhibition in the growth of human colon carcinoma HCT-116 xenograft
	Animal model	Human xenograft mode with HCT-116 tumor model (severe combined immunodeficient mice)
	Dosages	35 mg/kg
	Administration	Administered i.p.; daily for 10 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4886 mL	12.4428 mL	24.8855 mL	49.7711 mL
5mM	0.4977 mL	2.4886 mL	4.9771 mL	9.9542 mL
10mM	0.2489 mL	1.2443 mL	2.4886 mL	4.9771 mL
20mM	0.1244 mL	0.6221 mL	1.2443 mL	2.4886 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.