BMP signaling agonist sb4

This product is for research use only, not for human use. We do not sell to patients.

BMP signaling agonist sb4
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Size Price Stock
250mg$420Check With Us
500mg$650Check With Us
1g$975Check With Us

Cat #: V37829 CAS #: 100874-08-6 Purity ≥ 99%

Description: BMP signaling agonist sb4 is a novel and potent enzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist.

References: Bradford STJ, et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J Biol Chem. 2019 Mar 1; 294(9):3125-3136.

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Molecular Weight (MW)320.20
Molecular FormulaC14H10BrNOS
CAS No.100874-08-6
ProtocolIn VitroBMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) Dose-dependent induction of PREC cell phosphorylation of SMAD-1/5/9 under serum starvation conditions
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1230 mL15.6152 mL31.2305 mL62.4610 mL
5mM0.6246 mL3.1230 mL6.2461 mL12.4922 mL
10mM0.3123 mL1.5615 mL3.1230 mL6.2461 mL
20mM0.1562 mL0.7808 mL1.5615 mL3.1230 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Concentration(final)
C2
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.