A83-01
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $350 | Check With Us |
| 250mg | $560 | Check With Us |
| 500mg | $840 | Check With Us |
: Cat #: V7153 CAS #: 909910-43-6 Purity ≥ 98%
Description: A-83-01 is an ALK inhibibitor.
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| Molecular Weight (MW) | 421.52 |
|---|---|
| Molecular Formula | C25H19N5S |
| CAS No. | 909910-43-6 |
| Protocol | In Vitro | A 83-01 is a potent inhibitor of TGF-β type I receptors ALK5 kinase, ALK4, and ALK7, reducing ALK-1-induced transcription levels in Mv5Lu cells, IC50 At 12 nM, ALK4-TD and ALK7-TD-induced transcription were also blocked, IC in R4-2 cells50 45 nM and 7.5 nM, respectively, and weakly inhibited transcription induced by constitutive active ALK-6, ALK-2, ALK-3, and ALK-1. A 83-01 (0.03-10 μM) effectively blocks the growth inhibition of TGF-β and completely inhibits it at 3 μM. A 83-01 (1-10 μM) inhibits TGF-β-induced Smad activation in HaCaT cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3724 mL | 11.8618 mL | 23.7237 mL | 47.4473 mL |
| 5mM | 0.4745 mL | 2.3724 mL | 4.7447 mL | 9.4895 mL |
| 10mM | 0.2372 mL | 1.1862 mL | 2.3724 mL | 4.7447 mL |
| 20mM | 0.1186 mL | 0.5931 mL | 1.1862 mL | 2.3724 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.