RepSox (SJN 2511)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$480	In Stock
250mg	$890	In Stock
500mg	$1335	In Stock

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Cat #: V1373 CAS #: 446859-33-2 Purity ≥ 98%

Description: RepSox (also called E-616452, SJN-2511; E 616452; SJN 2511, and ALK5 Inhibitor II) is a potent, cell permeable, and selective inhibitor of the TGFβR-1/ALK5 (transforming growth factor-beta type I receptor, ALK5) with important biological activity.

References: Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	287.32
Molecular Formula	C17H13N5
CAS No.	446859-33-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 57 mg/mL (198.4 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	CC1=CC=CC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=N1
Synonyms	E-616452, SJN 2511; E 616452; E616452; RepSox; SJN-2511; SJN-2511; ALK5 Inhibitor II Chemical Name: 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine Exact Mass: 287.1171

Protocol	In Vitro	RepSox (compound 19) inhibits ALK5 autophosphorylation with an IC50 value of 4 nM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.4804 mL	17.4022 mL	34.8044 mL	69.6088 mL
5mM	0.6961 mL	3.4804 mL	6.9609 mL	13.9218 mL
10mM	0.3480 mL	1.7402 mL	3.4804 mL	6.9609 mL
20mM	0.1740 mL	0.8701 mL	1.7402 mL	3.4804 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.