LDN-214117
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | Check With Us |
| 500mg | $1650 | Check With Us |
| 1g | $2475 | Check With Us |
: Cat #: V1365 CAS #: 1627503-67-6 Purity ≥ 98%
Description: LDN-214117 (LDN 214117; LDN214117) is a novel, potent and selective ALK2 (BMP type I receptor kinase) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 419.52 |
|---|---|
| Molecular Formula | C25H29N3O3 |
| CAS No. | 1627503-67-6 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 83 mg/mL (197.8 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 83 mg/mL (197.8 mM) | |
| Synonyms | LDN214117; LDN 214117; LDN-214117 |
| Protocol | In Vitro | LDN-214117 has high inhibition and selectivity for ALK2 kinase proteins with an IC50 value of 24 nM. LDN-214117 has kinase activity for ALK1, ALK3 and ALK5 with IC50 values of 27 nM, 1,171 nM and 3,000 nM, respectively. LDN-214117 exhibits relatively selective inhibition for BMP6, BMP2 and BMP4 with IC50 values of 100 nM, 1,022 nM and 960 nM, respectively. LDN-214117 has inhibition of TGF-β1-induced transcriptional activity with an IC50 values of 16,000 nM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3837 mL | 11.9184 mL | 23.8368 mL | 47.6735 mL |
| 5mM | 0.4767 mL | 2.3837 mL | 4.7674 mL | 9.5347 mL |
| 10mM | 0.2384 mL | 1.1918 mL | 2.3837 mL | 4.7674 mL |
| 20mM | 0.1192 mL | 0.5959 mL | 1.1918 mL | 2.3837 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.