LDN-212854
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2750 | Check With Us |
| 1g | $4125 | Check With Us |
: Cat #: V1370 CAS #: 1432597-26-6 Purity ≥ 98%
Description: LDN-212854 (LDN 212854; LDN212854) is a potent and selective inhibitor of BMP (bone morphogenetic protein) receptor with potential antineoplastic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 406.48 |
|---|---|
| Molecular Formula | C25H22N6 |
| CAS No. | 1432597-26-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 81 mg/mL (199.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | BMP Inhibitor III; LDN212854; LDN 212854; LDN-212854. |
| Protocol | In Vitro | LDN-212854 (0-3.815 μM) blocks the phosphorylation of SMAD1/5/8 induced by BMP7 in BMPR2−/− cells |
|---|---|---|
| In Vivo | LDN-212854 (intraperitoneal injection, 6 mg/kg, twice daily for 4 weeks) potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva | |
| Animal model | Murine inducible transgenic ALK2Q207D model of heterotopic ossification | |
| Dosages | 6 mg/kg | |
| Administration | Intraperitoneal injection , twice daily for 4 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4601 mL | 12.3007 mL | 24.6015 mL | 49.2029 mL |
| 5mM | 0.4920 mL | 2.4601 mL | 4.9203 mL | 9.8406 mL |
| 10mM | 0.2460 mL | 1.2301 mL | 2.4601 mL | 4.9203 mL |
| 20mM | 0.1230 mL | 0.6150 mL | 1.2301 mL | 2.4601 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.