SB525334
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $730 | In Stock |
| 500mg | $1150 | In Stock |
| 1g | $1725 | In Stock |
: Cat #: V1362 CAS #: 356559-20-1 Purity ≥ 98%
Description: SB525334 (SB-525334; SB 525334) is a potent and selective inhibitor of TGF-β (transforming growth factor-β) receptor I, ALK5 (activin receptor-like kinase) with potential anti-fibrotic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 343.42 |
|---|---|
| Molecular Formula | C21H21N5 |
| CAS No. | 356559-20-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 68 mg/mL (198.0 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 68 mg/mL (198.0 mM) | |
| Solubility In Vivo | 5% DMSO+corn oil: 20 mg/mL |
| Synonyms | SB 525334; SB-525334; SB525334 Chemical Name: 6-(2-(tert-butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline SMILES Code: CC1=CC=CC(C2=C(C3=CC=C4N=CC=NC4=C3)N=C(C(C)(C)C)N2)=N1 Exact Mass: 343.1797 |
| Protocol | In Vitro | SB525334 (1 μM; for 15 minutes before stimulating with 0.625 ng/ml of TGF-β1, assesses after 6 days) inhibits TGF-β1-mediated proliferation of familial idiopathic pulmonary arterial hypertension (iPAH) pulmonary artery smooth muscle cells (PASMCs) at an IC50 of 295 nM |
|---|---|---|
| In Vivo | SB525334 (3-30 mg/kg; p.o.; daily from days 17 to 35) significantly reverses pulmonary arterial pressure in a rat model of pulmonary arterial hypertension (PAH) | |
| Animal model | Adult male Sprague-Dawley rats (MCT rat model of pulmonary hypertension) | |
| Dosages | 3, 30 mg/kg | |
| Administration | Oral administration; daily from days 17 to 35 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9119 mL | 14.5594 mL | 29.1189 mL | 58.2377 mL |
| 5mM | 0.5824 mL | 2.9119 mL | 5.8238 mL | 11.6475 mL |
| 10mM | 0.2912 mL | 1.4559 mL | 2.9119 mL | 5.8238 mL |
| 20mM | 0.1456 mL | 0.7280 mL | 1.4559 mL | 2.9119 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.