HT-2157
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1900 | Check With Us |
| 250mg | $2800 | Check With Us |
| 500mg | $4200 | Check With Us |
: Cat #: V2783 CAS #: 303149-14-6 Purity ≥ 98%
Description: HT-2157 (also known as SNAP 37889) is a selective, high-affinity, and competitive antagonists of galanin-3 receptor (Gal3) that has the potential for the treatment of major depressive disorder.
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| Molecular Weight (MW) | 366.34 |
|---|---|
| Molecular Formula | C21H13F3N2O |
| CAS No. | 303149-14-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 29 mg/mLr |
| Water: < 1 mg/mLr | |
| Ethanol: < 1 mg/mL | |
| Synonyms | HT-2157; HT2157; HT 2157; SNAP37889; SNAP 37889; SNAP-37889; |
| Protocol | In Vitro | HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK- cells expressing the human Gal3 receptor (Ki=17.44±0.01 nM; n>100) and is highly selective for Gal3 over the Gal1 and Gal2 subtypes (Ki>10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7297 mL | 13.6485 mL | 27.2970 mL | 54.5941 mL |
| 5mM | 0.5459 mL | 2.7297 mL | 5.4594 mL | 10.9188 mL |
| 10mM | 0.2730 mL | 1.3649 mL | 2.7297 mL | 5.4594 mL |
| 20mM | 0.1365 mL | 0.6824 mL | 1.3649 mL | 2.7297 mL |
The molarity calculator equation
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.