Danuglipron (PF-06882961)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1600 | Check With Us |
| 500mg | $2500 | Check With Us |
| 1g | $3750 | Check With Us |
: Cat #: V37568 CAS #: 2230198-02-2 Purity ≥ 99%
Description: Danuglipron (PF-06882961; PF06882961) is a novel, non-peptide, allosteric and orally bioavailable agonist of the glucagon-like peptide-1 receptor (GLP-1R).
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- Related Biological Data
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| Molecular Weight (MW) | 555.6104 |
|---|---|
| Molecular Formula | C31H30FN5O4 |
| CAS No. | 2230198-02-2 |
| Protocol | In Vitro | For example, a methylene-linked oxetane increased potency ∼100-fold relative to the methyl substituent of 5, leading to the identification of PF-06882961, which is a full agonist (EC50 = 13 nM) in the CS cAMP assay (Fig. 3A, Table S2). PF-06882961 also incorporates a nitrile replacement for the chloride in the benzyl ether region, which served to reduce CLint in HLM as well as in human hepatocytes (Table S4). |
|---|---|---|
| In Vivo | Intravenous infusion of PF-06882961 during the IVGTT led to an increase in insulin secretion and the rate of glucose disappearance (K-value) (Fig. 5B–D). Enhancement of glucose-stimulated insulin secretion by PF-06882961 was concentration-dependent and was also observed following oral dosing with similar efficacy when compared to administration by IV infusion (Fig. 5E). Once-daily administration of PF-06882961 for 2 days also inhibited food intake compared to vehicle-treated monkeys (Fig. 5F) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7998 mL | 8.9991 mL | 17.9982 mL | 35.9964 mL |
| 5mM | 0.3600 mL | 1.7998 mL | 3.5996 mL | 7.1993 mL |
| 10mM | 0.1800 mL | 0.8999 mL | 1.7998 mL | 3.5996 mL |
| 20mM | 0.0900 mL | 0.4500 mL | 0.8999 mL | 1.7998 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.