Cangrelor sodium

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$800	Check With Us
250mg	$1450	Check With Us
500mg	$2175	Check With Us

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Cat #: V23187 CAS #: 163706-36-3 Purity ≥ 99%

Description: Cangrelor sodium (ARC69931MX; AR-C69931; Kengreal, CANREAL; Kengrexal), the tetra-sodium salt of cangrelor which is an ATP analog, is a reversible, selective and direct-acting P2Y12 inhibitor approved in June 2015 as an antiplatelet drug for intravenous application.

References: Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92.

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Molecular Weight (MW)	864.29
Molecular Formula	C17H21Cl2F3N5Na4O12P3S2
CAS No.	163706-36-3

Protocol	In Vivo	Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.1570 mL	5.7851 mL	11.5702 mL	23.1404 mL
5mM	0.2314 mL	1.1570 mL	2.3140 mL	4.6281 mL
10mM	0.1157 mL	0.5785 mL	1.1570 mL	2.3140 mL
20mM	0.0579 mL	0.2893 mL	0.5785 mL	1.1570 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.