VU0453379

This product is for research use only, not for human use. We do not sell to patients.

VU0453379
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
25mg$1290To Be Confirmed
50mg$1935To Be Confirmed
100mg$2900To Be Confirmed

Cat #: V28095 CAS #: 1638646-27-1 Purity ≥ 99%

Description: VU0453379 (VU-0453379; VU 0453379) is a novel, CNS-penetrant and potent glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM) with EC50 of 1.3 μM.

References: Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (P

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Molecular Weight (MW)434.57
Molecular FormulaC26H34N4O2
CAS No.1638646-27-1
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3011 mL11.5056 mL23.0113 mL46.0225 mL
5mM0.4602 mL2.3011 mL4.6023 mL9.2045 mL
10mM0.2301 mL1.1506 mL2.3011 mL4.6023 mL
20mM0.1151 mL0.5753 mL1.1506 mL2.3011 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.