L-168,049
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $700 | To Be Confirmed |
| 100mg | $1050 | To Be Confirmed |
| 200mg | $1575 | To Be Confirmed |
: Cat #: V20593 CAS #: 191034-25-0 Purity ≥ 99%
Description: L-168,049 (L 168,049; L168,049) is a novel, selective, orally bioactive and non-peptidyl antagonist of human glucagon receptor (GR) with anti-diabetic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 467.79 |
|---|---|
| Molecular Formula | C24H20BrClN2O |
| CAS No. | 191034-25-0 |
| Protocol | In Vivo | In the liver of L-G6pc−/- mice, Pck1 mRNA expression is decreased by half 6 h after the administration of L-168049 (50 mg/kg body; p.o.), demonstrating the efficiency of the suppression of glucagon signaling. In agreement with the role of glucagon in the induction of extrahepatic gluconeogenesis, the administration of the L-168049 prevents the increase of the G6pc expression in both the kidneys and intestine of 6 h-fasted L-G6pc−/- mice |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1377 mL | 10.6886 mL | 21.3771 mL | 42.7542 mL |
| 5mM | 0.4275 mL | 2.1377 mL | 4.2754 mL | 8.5508 mL |
| 10mM | 0.2138 mL | 1.0689 mL | 2.1377 mL | 4.2754 mL |
| 20mM | 0.1069 mL | 0.5344 mL | 1.0689 mL | 2.1377 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.