SEMAGLUTIDE TFA | CAS 910463-68-2 (free base)

SEMAGLUTIDE TFA

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Size	Price	Stock
50mg	$1350	Check With Us
100mg	$2025	Check With Us
200mg	$3035	Check With Us

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Cat #: V3909 CAS #: 910463-68-2 (free base) Purity ≥ 98%

Description: Semaglutide TFA (NNC0113-0217; NNC-0113-0217), the trifluoroacetic acid salt form of semaglutide (brand name: Ozempic), is a human glucagon-like peptide-1 (GLP-1) analogue acting as a GLP-1 receptor agonist with longer duration of antidiabetic action.

References: Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	4227.66
Molecular Formula	C189H292F3N45O61 Exact Mass: 4225.11 Molecular Weight: 4227.66 m/z: 4227.11 (100.0%), 4226.11 (98.4%), 4225.11 (48.1%), 4228.12 (42.3%), 4229.12 (33.4%), 4228.12 (25.1%), 4228.11 (16.6%), 4227.11 (16.3%), 4229.12 (12.5%), 4228.12 (12.3%), 4226.11 (8.0%), 4230.13 (7.6%), 4229.12 (7.0%), 4227.11 (6.0%), 4230.12 (5.3%), 4230.12 (4.8%), 4230.13 (4.7%), 4229.12 (4.2%), 4230.12 (2.9%), 4231.13 (1.9%) Elemental Analysis: C, 53.70; H, 6.96; F, 1.35; N, 14.91; O, 23.08
CAS No.	910463-68-2 (free base)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	O=C(O)CNC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(O)=O)NC ([C@H](CCCCNC(C(C(COCCOCCN)=O)(C(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)OCCOCCN) =O)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC= C(O)C=C4)NC([C@@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC ([C@H](CC5=CC=CC=C5)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(O)=O)NC(C(C)(C)NC([C@H](CC6=CNC=N6)N)=O) =O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O) =O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Synonyms	NNC 0113-0217 TFA; NNC 0113-0217; NNC-0113-0217; NNC-0113 0217

Protocol	In Vitro	Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM
Protocol	In Vivo	The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.2365 mL	1.1827 mL	2.3654 mL	4.7307 mL
5mM	0.0473 mL	0.2365 mL	0.4731 mL	0.9461 mL
10mM	0.0237 mL	0.1183 mL	0.2365 mL	0.4731 mL
20mM	0.0118 mL	0.0591 mL	0.1183 mL	0.2365 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.