Insulinotropin acetate [GLP-1 (7-37)]
This product is for research use only, not for human use. We do not sell to patients.
![Insulinotropin acetate [GLP-1 (7-37)]](https://invivochem.net/wp-content/uploads/2023/05/6377430184094283081931656434-300x184.gif "Insulinotropin acetate [GLP-1 (7-37)]")
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25mg | $1250 | To Be Confirmed |
| 50mg | $1875 | To Be Confirmed |
| 100mg | $2810 | To Be Confirmed |
: Cat #: V16459 CAS #: 106612-94-6 (free base) Purity ≥ 99%
Description: GLP-1(7-37) acetate [also known as Tglp-1 and Insulinotropin], the acetate salt of GLP-1(7-37), is a novel insulinotropic hormone generated from the precursor peptide GLP-1 (1-37).
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| Molecular Weight (MW) | 3355.67 |
|---|---|
| Molecular Formula | C151H228N40O47 |
| CAS No. | 106612-94-6 (free base) |
| Protocol | In Vivo | GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats |
|---|---|---|
| Animal model | Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM | |
| Dosages | Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM | |
| Administration | IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.2980 mL | 1.4900 mL | 2.9800 mL | 5.9601 mL |
| 5mM | 0.0596 mL | 0.2980 mL | 0.5960 mL | 1.1920 mL |
| 10mM | 0.0298 mL | 0.1490 mL | 0.2980 mL | 0.5960 mL |
| 20mM | 0.0149 mL | 0.0745 mL | 0.1490 mL | 0.2980 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.