LGD-6972
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | Check With Us |
| 250mg | $3350 | Check With Us |
| 500mg | $5025 | Check With Us |
: Cat #: V2961 CAS #: 1207989-09-0 Purity ≥ 98%
Description: LGD-6972 (LGD6972; MB-11262) is a novel and orally bioavailable glucagon receptor antagonist with the potential to be used for treating type 2 diabetes (T2DM).
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 702.9 |
|---|---|
| Molecular Formula | C43H46N2O5S |
| CAS No. | 1207989-09-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 31 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | MB11262; LGD6972; MB 11262; LGD 6972; MB-11262; LGD-6972 |
| Protocol | In Vitro | In vitro, LGD-6972 binds competitively to glucagon receptor (GCGR) with high affinity and selectivity, suppressing both cAMP and glucose production |
|---|---|---|
| In Vivo | In vivo, LGD-6972 reduces acute glucagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting glucagon receptor signaling |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4227 mL | 7.1134 mL | 14.2268 mL | 28.4535 mL |
| 5mM | 0.2845 mL | 1.4227 mL | 2.8454 mL | 5.6907 mL |
| 10mM | 0.1423 mL | 0.7113 mL | 1.4227 mL | 2.8454 mL |
| 20mM | 0.0711 mL | 0.3557 mL | 0.7113 mL | 1.4227 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.