BX-471 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $915 | Check With Us |
| 500mg | $1260 | Check With Us |
| 1g | $1890 | Check With Us |
: Cat #: V3785 CAS #: 288262-96-4 Purity ≥ 98%
Description: BX471 HCl (also known as BX-471; ZK-811752) is a novel, oral and non-peptide antagonist of CCR1 (CC chemokine receptor-1) with potential anti-inflammatory activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 471.35 |
|---|---|
| Molecular Formula | C21H25Cl2FN4O3 |
| CAS No. | 288262-96-4 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 50 mg/mLrr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | C[C@H]1N(C(COC2=CC=C(Cl)C=C2NC(N)=O)=O)CCN(CC3=CC=C(F)C=C3)C1.[H]Cl |
| Synonyms | ZK811752 HCl; BX471 HCl; ZK 811752; BX 471; ZK-811752; BX-471 |
| Protocol | In Vitro | BX471 is a potent functional antagonist based on its ability to inhibit a number of CCR1-mediated effects including Ca2+ mobilization, increase in extracellular acidification rate, CD11b expression, and leukocyte migration. BX471 demonstrats a greater than 10,000-fold selectivity for CCR1 compared with 28 G-protein-coupled receptors |
|---|---|---|
| In Vivo | BX471 (4 mg/kg, p.o. or i.v.) is orally active with a bioavailability of 60% in dogs. Furthermore, BX471 effectively reduces disease in a rat experimental allergic encephalomyelitis model of multiple sclerosis |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1216 mL | 10.6078 mL | 21.2157 mL | 42.4313 mL |
| 5mM | 0.4243 mL | 2.1216 mL | 4.2431 mL | 8.4863 mL |
| 10mM | 0.2122 mL | 1.0608 mL | 2.1216 mL | 4.2431 mL |
| 20mM | 0.1061 mL | 0.5304 mL | 1.0608 mL | 2.1216 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.