Xanomeline oxalate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1240 | To Be Confirmed |
| 500mg | $1750 | To Be Confirmed |
| 1g | $2625 | To Be Confirmed |
: Cat #: V4900 CAS #: 141064-23-5 (oxalate) Purity ≥ 98%
Description: Xanomeline oxalate (also known as LY246708) is a novel, potent and selective M1 muscarinic receptor agonist with good selectivity for the M1 and M4 subtypes.
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| Molecular Weight (MW) | 371.45 |
|---|---|
| Molecular Formula | C16H25N3O5S |
| CAS No. | 141064-23-5 (oxalate) |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells. Xanomeline inhibits [3H]-pirenzepine ([3H]-PZ) and [3H]-oxotremorine-M ([3H]-OXO-M) binding to rat brain with Kis of 7 and 3 nM, respectively |
|---|---|---|
| In Vivo | Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 8.1 μmole/kg in hippocampus |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6922 mL | 13.4608 mL | 26.9215 mL | 53.8430 mL |
| 5mM | 0.5384 mL | 2.6922 mL | 5.3843 mL | 10.7686 mL |
| 10mM | 0.2692 mL | 1.3461 mL | 2.6922 mL | 5.3843 mL |
| 20mM | 0.1346 mL | 0.6730 mL | 1.3461 mL | 2.6922 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.