VU0357017 HCI
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $730 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V3036 CAS #: 1135242-13-5 Purity ≥ 98%
Description: VU0357017 HCI (formerly CID-25010775) is a potent and highly selective M1 agonists that appear to act at an allosteric site to activate the receptor with EC50 of 477 ± 172 nM and pEC50 of 6.37 ± 0.15).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 369.89 |
|---|---|
| Molecular Formula | C18H28ClN3O3 |
| CAS No. | 1135242-13-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 33 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | CID 25010775, CID25010775, CID-25010775; VU0357017, VU-0357017, VU 0357017 |
| Protocol | In Vivo | VU0357017 (1-10 mg/kg, i.p.) reverses scopolamine-induced disruption of the contextual fear conditioning response |
|---|---|---|
| Animal model | Male Sprague−Dawley rats (380-420 g) were pretreated with scopolamine | |
| Dosages | 1, 3, 10 mg/kg | |
| Administration | A single i.p. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7035 mL | 13.5175 mL | 27.0351 mL | 54.0701 mL |
| 5mM | 0.5407 mL | 2.7035 mL | 5.4070 mL | 10.8140 mL |
| 10mM | 0.2704 mL | 1.3518 mL | 2.7035 mL | 5.4070 mL |
| 20mM | 0.1352 mL | 0.6759 mL | 1.3518 mL | 2.7035 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.