DREADD agonist 21
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $450 | Check With Us |
| 100mg | $750 | Check With Us |
| 200mg | $1125 | Check With Us |
: Cat #: V20245 CAS #: 56296-18-5 Purity ≥ 98%
Description: DREADD agonist 21 is a muscarinic hM3Dq DREADD receptor agonist.
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| Molecular Weight (MW) | 278.35 |
|---|---|
| Molecular Formula | C17H18N4 |
| CAS No. | 56296-18-5 |
| Protocol | In Vitro | DREADD agonist 21 effectively activates hM1Dq, hM3Dq, and hM4Di. DREADD agonist 21 binds to hM1, hM4, hM1Dq, and hM4Di receptors, pKi 5.97, 5.44, 7.20, and 6.75, respectively. DREADD agonist 21 effectively activates hM3Dq,pEC in Chinese hamster ovary (CHO) transfected cells in vitro50 is 8.48±0.05. DREADD agonist 21 is a highly selective and potent muscarinic DREADD agonist (pEC with hM1Dq=6.54 and hM4Di=7.77 in pERK assays50) |
|---|---|---|
| In Vivo | DREADD agonist 21 has excellent bioavailability, pharmacokinetic properties and brain permeability. DREADD agonist 21 (0.1, 1, and 10 mg/kg; ip) exhibited 95.1% plasma protein binding and 95% brain protein binding in mice |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5926 mL | 17.9630 mL | 35.9260 mL | 71.8520 mL |
| 5mM | 0.7185 mL | 3.5926 mL | 7.1852 mL | 14.3704 mL |
| 10mM | 0.3593 mL | 1.7963 mL | 3.5926 mL | 7.1852 mL |
| 20mM | 0.1796 mL | 0.8981 mL | 1.7963 mL | 3.5926 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.