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| Size | Price | Stock |
|---|---|---|
| 250mg | $899 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V3999 CAS #: 2253744-53-3 Purity ≥ 98%
Description: DJ-V-159 is a novel and potent agonist for G protein-coupled receptor family C group 6 member A (GPRC6A) with the potential for treating type 2 diabetes mellitus (T2D).
References: Pi M, et al. Computationally identified novel agonists for GPRC6A. PLoS One. 2018 Apr 23;13(4):e0195980.
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| Molecular Weight (MW) | 502.37 |
|---|---|
| Molecular Formula | C₂₄H₁₂F₆N₄O₂ |
| CAS No. | 2253744-53-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 20 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(C1=CC(C(NC2=CC(C(F)(F)F)=C(C#N)C=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3 |
| Synonyms | DJ-V-159; DJ V-159; DJ-V 159 |
| Protocol | In Vitro | DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A |
|---|---|---|
| In Vivo | DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9906 mL | 9.9528 mL | 19.9056 mL | 39.8113 mL |
| 5mM | 0.3981 mL | 1.9906 mL | 3.9811 mL | 7.9623 mL |
| 10mM | 0.1991 mL | 0.9953 mL | 1.9906 mL | 3.9811 mL |
| 20mM | 0.0995 mL | 0.4976 mL | 0.9953 mL | 1.9906 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.