ML-193

This product is for research use only, not for human use. We do not sell to patients.

ML-193
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$2000To Be Confirmed
1g$3000To Be Confirmed
5g$8100To Be Confirmed

Cat #: V25659 CAS #: 713121-80-3 Purity ≥ 98%

Description: ML-193 (ML193; CID-1261822; CID1261822) is a novel and potent GPR55 (G protein-coupled receptor 55) antagonist with IC50 of 221 nM.

References: Kotsikorou E, et, al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69.

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Product Promise

Promise
Molecular Weight (MW)527.59
Molecular FormulaC28H25N5O4S
CAS No.713121-80-3
ProtocolIn VitroML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC50s of 0.22 μM and 0.12 μM, respectively
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8954 mL9.4771 mL18.9541 mL37.9082 mL
5mM0.3791 mL1.8954 mL3.7908 mL7.5816 mL
10mM0.1895 mL0.9477 mL1.8954 mL3.7908 mL
20mM0.0948 mL0.4739 mL0.9477 mL1.8954 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.